Pharmacokinetic interaction between methotrexate and chloral hydrate1. Issue 3 (14th November 2012)

• Record Type: Journal Article
• Authors: Dao, Kim; Ivanyuk, Anton; Buclin, Thierry; Beck‐Popovic, Maja; Diezi, Manuel
• Is Part Of: Pediatric blood & cancer. Volume 60:Issue 3(2013:Mar.)
• Page Start: 518
• Page End: 520
• Publication Date: 2012-11-14
• Subjects: Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.24393
• Languages: English
• ISSNs: 1545-5009

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>We report the case of a drug interaction between methotrexate (MTX) and chloral hydrate (CH) observed in a child treated for acute leukemia. Significantly slower MTX clearance and increased MTX exposure occurred on the first three courses of a high‐dose chemotherapy when co‐administered with CH despite normal renal function, adequate hydration, and alkalinization. Mean MTX area under the curve associated with CH administration was 1, 134 µmol hours/L, compared to 608 µmol hours/L after discontinuation of CH. This interaction possibly resulted from a competition between anionic CH metabolites and MTX for renal tubular excretion. Pediatr Blood Cancer 2013; 60: 518–520. © 2012 Wiley Periodicals, Inc.</p> </abstract>