Are polymorphisms of the β3‐adrenoceptor gene associated with an altered bladder function?12. Issue 3 (12th September 2012)

• Record Type: Journal Article
• Authors: Teitsma, Christine A.; de la Rosette, Jean J.M.C.H.; Michel, Martin C.
• Is Part Of: Neurourology and urodynamics. Volume 32:Issue 3(2013:Mar.)
• Page Start: 276
• Page End: 280
• Publication Date: 2012-09-12
• Subjects: Urinary organs -- Periodicals; Urodynamics -- Periodicals; Urology -- Periodicals; 616.6
• DOI: 10.1002/nau.22305
• Languages: English
• ISSNs: 0733-2467

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Aims</title> <p>As the presence of a Trp64Arg polymorphism of the gene encoding the β<sub>3</sub>‐adrenoceptor (B3AR) has been linked to the presence of overactive bladder, we investigated whether additional polymorphisms are detectable in this gene and explore their relationships parameters related to lower urinary tract function.</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Methods</title> <p>The coding region and adjacent stretches of the B3AR gene was sequenced in 91 patients. In total, 1015 patients from a single academic hospital were genotyped for the presence of two single nucleotide polymorphisms. Symptom scores and parameters from pressure‐flow studies were analyzed relative to genotype in the B3AR gene.</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Results</title> <p>No frequent novel polymorphisms were detected in the coding region. Five polymorphisms were found in the non‐coding region of the gene but were in complete linkage with the 64Arg allele. Out of 32 parameters including bladder compliance, only prostate size was weakly (44 vs. 39 mL) but significantly associated with the 64Arg allele, but was not mirrored by an association with prostate‐specific antigen levels.</p> </sec> <sec id="abs1-4" sec-type="section"> <title>Conclusions</title> <p>Our data do not support the hypothesis that polymorphisms in the B3AR gene are associated with alterations of bladder function. Neurourol. Urodynam. 32: 276–280, 2013. © 2012 Wiley Periodicals, Inc.</p> </sec> </abstract>