Improvement of the compressive strength of a cuttlefish bone‐derived porous hydroxyapatite scaffold via polycaprolactone coating. Issue 7 (10th May 2013)

• Record Type: Journal Article
• Authors: Kim, Beom‐Su; Kang, Hyo Jin; Lee, Jun
• Is Part Of: Journal of biomedical materials research. Volume 101:Issue 7(2013:Oct.)
• Page Start: 1302
• Page End: 1309
• Publication Date: 2013-05-10
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/jbm.b.32943
• Languages: English
• ISSNs: 1552-4973

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>Cuttlefish bones (CBs) have emerged as attractive biomaterials because of their porous structure and components that can be converted into hydroxyapatite (HAp) via a hydrothermal reaction. However, their brittleness and low strength restrict their application in bone tissue engineering. Therefore, to improve the compressive strength of the scaffold following hydrothermal conversion to a HAp form of CB (CB‐HAp), the scaffold was coated using a polycaprolactone (PCL) polymer at various concentrations. In this study, raw CB was successfully converted into HAp via a hydrothermal reaction. We then evaluated their surface properties and composition by scanning electron microscopy and X‐ray diffraction analysis. The CB‐HAp coated with PCL showed improved compressive performance and retained a microporous structure. The compressive strength was significantly increased upon coating with 5 and 10% PCL, by 2.09‐ and 3.30‐fold, respectively, as compared with uncoated CB‐HAp. However, coating with 10% PCL resulted in a reduction in porosity. Furthermore, an <italic>in vitro</italic> biological evaluation demonstrated that MG‐63 cells adhered well, proliferated and were able to be differentiated on the PCL‐coated CB‐HAp scaffold, which was noncytotoxic. These results suggest that a simple coating method is useful to improve the compressive strength of CB‐HAp for bone tissue engineering applications. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 101B: 1302–1309, 2013.</p> </abstract>