In vivo assessment of amyloid‐β deposition in nondemented very elderly subjects. Issue 6 (17th April 2013)

• Record Type: Journal Article
• Authors: Mathis, Chester A.; Kuller, Lewis H.; Klunk, William E.; Snitz, Beth E.; Price, Julie C.; Weissfeld, Lisa A.; Rosario, Bedda L.; Lopresti, Brian J.; Saxton, Judith A.; Aizenstein, Howard J.; McDade, Eric M.; Kamboh, M. Ilyas; DeKosky, Steven T.; Lopez, Oscar L.
• Is Part Of: Annals of neurology. Volume 73:Issue 6(2013:Jun.)
• Page Start: 751
• Page End: 761
• Publication Date: 2013-04-17
• Subjects: Neurology -- Periodicals; Pediatric neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; 616.8
• DOI: 10.1002/ana.23797
• Languages: English
• ISSNs: 0364-5134

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ana23797-sec-0001" sec-type="section"> <title>Objective</title> <p>This study examined amyloid‐β (Aβ) deposition in 190 nondemented subjects aged ≥82 years to determine the proportion of Aβ‐positive scans and associations with cognition, apolipoprotein E (APOE) status, brain volume, and <italic>Ginkgo biloba (Gb</italic>) treatment.</p> </sec> <sec id="ana23797-sec-0002" sec-type="section"> <title>Methods</title> <p>Subjects who agreed to participate had a brain magnetic resonance imaging and positron emission tomography scan with <sup>11</sup>C‐labeled Pittsburgh compound B (PiB) following completion of a <italic>Gb</italic> treatment clinical trial. The youngest subject in this imaging study was 82 years, and the mean age of the subjects was 85.5 years at the time of the scans; 152 (80%) were cognitively normal, and 38 (20%) were diagnosed with mild cognitive impairment (MCI) at the time of the PiB study.</p> </sec> <sec id="ana23797-sec-0003" sec-type="section"> <title>Results</title> <p>A high proportion of the cognitively normal subjects (51%) and MCI subjects (68%) were PiB‐positive. The <italic>APOE*4</italic> allele was more prevalent in PiB‐positive than in PiB‐negative subjects (30% vs 6%). Measures of memory, language, and attentional functions were worse in PiB‐positive than in PiB‐negative subjects, when both normal and MCI cases were analyzed together; however, no significant associations were observed within either normal or MCI subject groups alone. There was no relationship between <italic>Gb</italic> treatment and Aβ deposition as determined by PiB.</p> </sec> <sec id="ana23797-sec-0004" sec-type="section"> <title>Interpretation</title> <p>The data revealed a 55% prevalence of PiB positivity in nondemented subjects age >80 years and 85% PiB positivity in the <italic>APOE*4</italic> nondemented elderly subjects. The findings also showed that long‐term exposure to <italic>Gb</italic> did not affect the prevalence of cerebral Aβ deposition. ANN NEUROL 2013;73:751–761</p> </sec> </abstract>