Myositis with antimitochondrial antibodies diagnosed by rectus abdominis muscle biopsy. Issue 5 (4th April 2013)

• Record Type: Journal Article
• Authors: Uenaka, Takeshi; Kowa, Hisatomo; Sekiguchi, Kenji; Nagata, Kakuya; Ohtsuka, Yoshihisa; Kanda, Fumio; Toda, Tatsushi
• Is Part Of: Muscle & nerve. Volume 47:Issue 5(2013:May)
• Page Start: 766
• Page End: 768
• Publication Date: 2013-04-04
• Subjects: Neuromuscular diseases -- Periodicals; Muscles -- Periodicals; Nerves -- Periodicals; 616.74
• DOI: 10.1002/mus.23730
• Languages: English
• ISSNs: 0148-639X

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <sec id="mus23730-sec-0001" sec-type="section"> <title>Introduction</title> <p>Antimitochondrial antibodies are autoantibodies detected in 90% of primary biliary cirrhosis (PBC) patients. Some PBC cases are complicated by myositis, which is difficult to confirm due to minimal histological evidence of inflammation in limb muscles.</p> </sec> <sec id="mus23730-sec-0002" sec-type="section"> <title>Methods</title> <p>Our aim was to determine the extent of inflammatory changes in a truncal muscle biopsy specimen from a PBC patient.</p> </sec> <sec id="mus23730-sec-0003" sec-type="section"> <title>Results</title> <p>A 48‐year‐old woman with a 5‐year history of atrial fibrillation and chronic heart failure was evaluated for elevated serum creatine kinase level. Antimitochondrial M2 antibodies were detected, and PBC was diagnosed. A biceps brachii biopsy specimen showed mild, non‐specific myogenic changes; a second biopsy was performed on the rectus abdominis muscle, which showed typical inflammatory changes. Myositis with antimitochondrial M2 antibodies was confirmed.</p> </sec> <sec id="mus23730-sec-0004" sec-type="section"> <title>Conclusions</title> <p>In myositis patients with antimitochondrial M2 antibodies, muscles of the extremities are involved to a lesser extent. Radiological and histological examination focusing on truncal muscles, including a biopsy, is important. Muscle Nerve 47: 766–768, 2013</p> </sec> </abstract>