Diabetes increases mechanical sensitivity and causes morphological abnormalities in the sural nerve that are prevented by treadmill training. Issue 1 (5th October 2012)

• Record Type: Journal Article
• Authors: Severo Do Nascimento, Patrícia; Lovatel, Gisele Agustini; Ilha, Jocemar; Schaan, Beatriz D'agord; Achaval, Matilde
• Is Part Of: Muscle & nerve. Volume 47:Issue 1(2013:Jan.)
• Page Start: 46
• Page End: 52
• Publication Date: 2012-10-05
• Subjects: Neuromuscular diseases -- Periodicals; Muscles -- Periodicals; Nerves -- Periodicals; 616.74
• DOI: 10.1002/mus.23450
• Languages: English
• ISSNs: 0148-639X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Introduction:</title> <p>In this investigation we evaluated the effects of treadmill training on mechanical sensitivity and sural nerve morphology in diabetic rats.</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Methods:</title> <p>Rats were divided into 3 groups: control (C); diabetic (D); and trained diabetic (TD). Training was performed for 8 weeks. Mechanical sensitivity was evaluated using von Frey filaments. Sural nerve analysis included fiber area, diameter, density of myelinated fibers, area occupied by connective tissue, myelin sheath thickness, and g‐ratio.</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Results:</title> <p>Animals in the D group had a reduced mechanical sensitivity threshold. Morphometric study showed that the D group had a smaller myelinated fiber area and diameter, higher density of fibers and area occupied by connective tissue, thinner myelin sheath, and higher g‐ratio. The D group had a higher percentage of small myelinated fibers and a lower percentage of large‐diameter myelinated fibers than the C and TD groups.</p> </sec> <sec id="abs1-4" sec-type="section"> <title>Conclusion:</title> <p>Training prevents functional and morphological abnormalities in the sural nerve caused by diabetes. Muscle Nerve, 2013</p> </sec> </abstract>