Diffusion‐weighted imaging for evaluation of uterine arterial embolization of fibroids. Issue 6 (25th February 2013)

• Record Type: Journal Article
• Authors: Faye, Nathalie; Pellerin, Olivier; Thiam, Rokhaya; Chammings, Foucauld; Brisa, Marie; Marques, Enio; Cuénod, Charles A.; Sapoval, Marc; Fournier, Laure S.
• Is Part Of: Magnetic resonance in medicine. Volume 70:Issue 6(2013:Dec.)
• Page Start: 1739
• Page End: 1747
• Publication Date: 2013-02-25
• Subjects: Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.24624
• Languages: English
• ISSNs: 0740-3194

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mrm24624-sec-0001" sec-type="section"> <title>Purpose</title> <p>To determine whether diffusion‐weighted imaging (DWI) characteristics could predict the effectiveness of uterine arterial embolization in treatment of fibroids.</p> </sec> <sec id="mrm24624-sec-0002" sec-type="section"> <title>Methods</title> <p>This retrospective study included 17 women (27 fibroids) who underwent uterine arterial embolization for fibroids. MR imaging (1.5 T) was performed before, 1 week and 6 months after uterine arterial embolization. The volume, T2 signal, T1 signal, enhancement after contrast media injection, DWI signal (<italic>b</italic> = 500 s/mm<sup>2</sup>) and apparent diffusion coefficient (ADC) were assessed for fibroids.</p> </sec> <sec id="mrm24624-sec-0003" sec-type="section"> <title>Results</title> <p>DWI signal or ADC, whether before or 1 week after the procedure, did not show a statistical relationship to success of uterine arterial embolization. On the 1‐week follow‐up, 22% of fibroids enhanced vs. 85% on baseline, <italic>P</italic> < 0.0001 and DW signal intensity increased. ADC values in fibroids decreased between baseline and 1‐week (1.61 vs. 1.53 × 10<sup>−3</sup> mm<sup>2</sup>/s, <italic>P</italic> = 0.13). On 6‐months, ADC continued to decrease compared with baseline (1.27 × 10<sup>−3</sup> mm<sup>2</sup>/s, <italic>P</italic> = 0.002), but with a lower signal on DWI. No changes were observed in myometrium ADC at any time point.</p> </sec> <sec id="mrm24624-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Our study demonstrated that DWI and ADC reflected early and delayed changes in fibroids after embolization; however, we were not able to demonstrate a statistically significant relationship with outcome. Magn Reson Med 70:1739–1747, 2013. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>