3D‐mapping of phosphocreatine concentration in the human calf muscle at 7 T: Comparison to 3 T. Issue 6 (6th February 2013)

• Record Type: Journal Article
• Authors: Parasoglou, Prodromos; Xia, Ding; Chang, Gregory; Regatte, Ravinder R.
• Is Part Of: Magnetic resonance in medicine. Volume 70:Issue 6(2013:Dec.)
• Page Start: 1619
• Page End: 1625
• Publication Date: 2013-02-06
• Subjects: Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.24616
• Languages: English
• ISSNs: 0740-3194

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mrm24616-sec-0001" sec-type="section"> <title>Purpose</title> <p>The development and implementation of a spectrally selective 3D‐Turbo Spin Echo sequence for quantitative mapping of phosphocreatine (PCr) concentration in different muscles of the lower leg of healthy volunteers both at 3 T and 7 T.</p> </sec> <sec id="mrm24616-sec-0002" sec-type="section"> <title>Methods</title> <p>Nine healthy volunteers were recruited, all of whom where scanned at 3 T and 7 T. Three dimensional PCr concentration maps were obtained after images were corrected for <italic>B</italic><sub>1</sub> inhomogeneities, <italic>T</italic><sub>1</sub> relaxation weighting, and partial volume of fatty tissue in the muscles. Two volunteers performed plantar flexions inside the magnet, and the oxidative capacity of their muscles was estimated.</p> </sec> <sec id="mrm24616-sec-0003" sec-type="section"> <title>Results</title> <p>Three dimensional PCr concentration maps were obtained, with full muscle coverage and nominal voxel size of 0.52 mL at both fields. At 7 T a 2.7‐fold increase of signal‐to‐noise ratio was achieved compared to 3 T.</p> </sec> <sec id="mrm24616-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Imaging <sup>31</sup>P metabolites at 7 T allowed for significant increase in signal to noise ratio compared to imaging at 3 T, while quantification of the PCr concentration remained unaffected. The importance of such an increase in signal‐to‐noise ratio is 2‐fold, first higher resolution images with reduced partial volume effects can be acquired, and second multiple measurements such as dynamic imaging of PCr post‐exercise, <sup>31</sup>P magnetization transfer, or other <sup>1</sup>H measurements, can be acquired in a single imaging session. Magn Reson Med 70:1619–1625, 2013. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>