In vivo free induction decay based 3D multivoxel longitudinal hadamard spectroscopic imaging in the human brain at 3 T. Issue 4 (10th May 2012)

• Record Type: Journal Article
• Authors: Tal, Assaf; Goelman, Gadi; Gonen, Oded
• Is Part Of: Magnetic resonance in medicine. Volume 69:Issue 4(2013:Apr.)
• Page Start: 903
• Page End: 911
• Publication Date: 2012-05-10
• Subjects: Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.24327
• Languages: English
• ISSNs: 0740-3194

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>We propose and demonstrate a full 3D longitudinal Hadamard spectroscopic imaging scheme for obtaining chemical shift maps, using adiabatic inversion pulses to encode the spins' positions. The approach offers several advantages over conventional Fourier‐based encoding methods, including a localized point spread function; no aliasing, allowing for volumes of interest smaller than the object being imaged; an option for acquiring noncontiguous voxels; and inherent outer volume rejection. The latter allows for doing away with conventional outer volume suppression schemes, such as point resolved spectroscopy (PRESS) and stimulated echo acquisition mode (STEAM), and acquiring non‐spin‐echo spectra with short acquisition delay times, limited only by the excitation pulse's duration. This, in turn, minimizes <italic>T</italic>₂ decay, maximizes the signal‐to‐noise ratio, and reduces J‐coupling induced signal decay. Results are presented for both a phantom and an in vivo healthy volunteer at 3 T. Magn Reson Med 69:903–911, 2013. © 2012 Wiley Periodicals, Inc.</p> </abstract>