NOrmalized MAgnetization Ratio (NOMAR) filtering for creation of tissue selective contrast maps. Issue 2 (12th April 2012)

• Record Type: Journal Article
• Authors: Liu, Guanshu; Chan, Kannie W. Y.; Song, Xiaolei; Zhang, Jiangyang; Gilad, Assaf A.; Bulte, Jeff W. M.; van Zijl, Peter C. M.; McMahon, Michael T.
• Is Part Of: Magnetic resonance in medicine. Volume 69:Issue 2(2013:Feb.)
• Page Start: 516
• Page End: 523
• Publication Date: 2012-04-12
• Subjects: Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.24271
• Languages: English
• ISSNs: 0740-3194

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>An MRI segmentation technique based on collecting two additional saturation transfer images is proposed as an aid for improved detection of chemical exchange saturation transfer agents. In this approach, the additional images are acquired at saturation frequencies of −12.5 and −50 ppm. Use of the ratio of these images allows differentiation of voxels with low magnetization transfer contrast (such as fat, cerebrospinal fluid, edema, or blood) from target tissue voxels using a global threshold determined by histogram analysis. We demonstrate that this technique can reduce artifacts, in vitro, in a phantom containing tubes with chemical exchange saturation transfer contrast agent embedded in either crosslinked bovine serum albumin or buffer, and in vivo for detecting diamagnetic CEST (DIACEST) liposomes injected into mice. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.</p> </abstract>