On the selectivity and efficacy of defense peptides with respect to cancer cells. Issue 1 (15th September 2011)

• Record Type: Journal Article
• Authors: Harris, Frederick; Dennison, Sarah R.; Singh, Jaipaul; Phoenix, David A.
• Is Part Of: Medicinal research reviews. Volume 33:Issue 1(2013:Jan.)
• Page Start: 190
• Page End: 234
• Publication Date: 2011-09-15
• Subjects: Pharmacology -- Periodicals; Drugs -- Research -- Periodicals; 615
• DOI: 10.1002/med.20252
• Languages: English
• ISSNs: 0198-6325

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Here, we review potential determinants of the anticancer efficacy of innate immune peptides (ACPs) for cancer cells. These determinants include membrane‐based factors, such as receptors, phosphatidylserine, sialic acid residues, and sulfated glycans, and peptide‐based factors, such as residue composition, sequence length, net charge, hydrophobic arc size, hydrophobicity, and amphiphilicity. Each of these factors may contribute to the anticancer action of ACPs, but no single factor(s) makes an overriding contribution to their overall selectivity and toxicity. Differences between the anticancer actions of ACPs seem to relate to different levels of interplay between these peptide and membrane‐based factors. © 2011 Wiley Periodicals, Inc. Med Res Rev</p> </abstract>