Intraoperative dopamine release during globus pallidus internus stimulation in Parkinson's disease. Issue 14 (21st October 2013)

• Record Type: Journal Article
• Authors: Martinez, Raquel C.R.; Hamani, Clement; de, Milene Cristina; de, Amanda Ribeiro; Alho, Eduardo; Navarro, Jessie; dos, Maria Gabriela; Bor‐Seng‐Shu, Edson; Heinsen, Helmut; Otoch, José Pinhata; Brandão, Marcus Lira; Barbosa, Egberto Reis; Teixeira, Manoel Jacobsen; Fonoff, Erich Talamoni
• Is Part Of: Movement disorders. Volume 28:Issue 14(2013)
• Page Start: 2027
• Page End: 2032
• Publication Date: 2013-10-21
• Subjects: Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.25691
• Languages: English
• ISSNs: 0885-3185

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <sec id="mds25691-sec-0001" sec-type="section"> <title>Background</title> <p>It is still unclear whether dopamine (DA) levels correlate with Parkinson's disease (PD) severity or play a role in the mechanisms of high‐frequency stimulation (HFS).</p> </sec> <sec id="mds25691-sec-0002" sec-type="section"> <title>Methods</title> <p>We have used microdialysis to record pallidal DA in 5 patients with PD undergoing microelectrode‐guided pallidotomy.</p> </sec> <sec id="mds25691-sec-0003" sec-type="section"> <title>Results</title> <p>We found that patients with more severe disease and, consequently, lower pallidal DA did poorly after pallidal lesions. In the operating room, 4 of 5 patients had a significant increase in DA levels during HFS (600%, on average). To test the hypothesis that DA was important for the effects of stimulation, we correlated the amelioration in rigidity observed in the operating room with pallidal DA release. Though rigidity was 56% better during stimulation, no correlation was found between such an improvement and DA release.</p> </sec> <sec id="mds25691-sec-0004" sec-type="section"> <title>Conclusions</title> <p>These findings suggest that additional mechanisms not directly dependent on pallidal DA release may be involved in the clinical effects of HFS of the globus pallidus internus. © 2013 International Parkinson and Movement Disorder Society</p> </sec> </abstract>