Subthalamus deep brain stimulation for primary dystonia patients: A long‐term follow‐up study. Issue 13 (16th July 2013)

• Record Type: Journal Article
• Authors: Cao, Chunyan; Pan, Yixin; Li, Dianyou; Zhan, Shikun; Zhang, Jing; Sun, Bomin
• Is Part Of: Movement disorders. Volume 28:Issue 13(2013)
• Page Start: 1877
• Page End: 1882
• Publication Date: 2013-07-16
• Subjects: Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.25586
• Languages: English
• ISSNs: 0885-3185

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <sec id="mds25586-sec-0001" sec-type="section"> <title>Background</title> <p>Deep brain stimulation has generated sustained improvement in motor function for patients with dystonia, but the long‐term impact of subthalamic nucleus stimulation on dystonia has not been elucidated.</p> </sec> <sec id="mds25586-sec-0002" sec-type="section"> <title>Methods</title> <p>Patients with primary dystonia underwent bilateral subthalamic nucleus stimulation and were evaluated with the Burke–Fahn–Marsden dystonia rating scale and the Medical Outcomes Study 36‐item Short‐Form General Health Survey at baseline and 1 month, 1 year, and 3 to 10 years postoperatively.</p> </sec> <sec id="mds25586-sec-0003" sec-type="section"> <title>Results</title> <p>Improvements in motor function according to the Burke–Fahn–Marsden dystonia rating scale at 1 month, 1 year, and 3 to 10 years of stimulation were 55%, 77%, and 79%, respectively. The quality of life improved after 1 month of stimulation (<italic>P</italic> < 0.001), progressed within 1 year (<italic>P</italic> < 0.001), and then remained stable. Disease duration was negatively correlated with an improvement in motor function.</p> </sec> <sec id="mds25586-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Our results demonstrate that the subthalamus is an alternative to the globus pallidus internus as a target for deep brain stimulation to treat primary dystonia. © 2013 International Parkinson and Movement Disorder Society</p> </sec> </abstract>