Better global and cognitive functioning in choreatic versus hypokinetic‐rigid Huntington's disease. Issue 8 (14th March 2013)

• Record Type: Journal Article
• Authors: Hart, Ellen P.; Marinus, Johan; Burgunder, Jean‐Marc; Bentivoglio, Anna Rita; Craufurd, David; Reilmann, Ralf; Saft, Carsten; Roos, Raymund A.C.
• Is Part Of: Movement disorders. Volume 28:Issue 8(2013)
• Page Start: 1142
• Page End: 1145
• Publication Date: 2013-03-14
• Subjects: Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.25422
• Languages: English
• ISSNs: 0885-3185

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mds25422-sec-0001" sec-type="section"> <title>Background</title> <p>Understanding the relation between predominantly choreatic and hypokinetic‐rigid motor subtypes and cognitive and general functioning may contribute to knowledge about different motor phenotypes in Huntington's disease.</p> </sec> <sec id="mds25422-sec-0002" sec-type="section"> <title>Methods</title> <p>In the European Huntington's Disease Network Registry study, 1882 subjects were classified as being predominantly choreatic (n = 528) or hypokinetic‐rigid (n = 432), according to their scores on items of the total motor score a priori labeled as choreatic or hypokinetic‐rigid; the other 922 patients were of a mixed type. The relationship between motor type and cognitive (verbal fluency, symbol digit modalities, Stroop color, word and interference tests) and functional (total functional capacity) capacity was investigated using multiple linear regression.</p> </sec> <sec id="mds25422-sec-0003" sec-type="section"> <title>Results</title> <p>Motor subtype contributed significantly to the total functional capacity score (partial <italic>r</italic><sup>2</sup>: 7.8%; <italic>P</italic> < .001) and to the 5 cognitive scores (partial <italic>r</italic><sup>2</sup> ranged from 2.0% to 8.4%; all <italic>P</italic> < .001).</p> </sec> <sec id="mds25422-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Patients with a predominantly choreatic motor phenotype performing better in all areas than patients with a hypokinetic‐rigid motor phenotype. © 2013 <italic>Movement</italic> Disorder Society</p> </sec> </abstract>