Genetic variability related to serum uric acid concentration and risk of Parkinson's disease. Issue 12 (27th May 2013)

• Record Type: Journal Article
• Authors: González‐Aramburu, Isabel; Sánchez‐Juan, Pascual; Jesús, Silvia; Gorostidi, Ana; Fernández‐Juan, Eduardo; Carrillo, Fátima; Sierra, María; Gómez‐Garre, Pilar; Cáceres‐Redondo, María T.; Berciano, José; Ruiz‐Martínez, Javier; Combarros, Onofre; Mir, Pablo; Infante, Jon
• Is Part Of: Movement disorders. Volume 28:Issue 12(2013)
• Page Start: 1737
• Page End: 1740
• Publication Date: 2013-05-27
• Subjects: Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.25507
• Languages: English
• ISSNs: 0885-3185

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <sec id="mds25507-sec-0001" sec-type="section"> <title>Background</title> <p>Low serum uric acid (UA) levels have been associated with increased Parkinson's disease (PD) risk and accelerated disease progression. We analyzed the effect of polymorphisms in 9 genes influencing serum UA concentration on the risk of PD.</p> </sec> <sec id="mds25507-sec-0002" sec-type="section"> <title>Methods</title> <p>We genotyped <italic>SLC2A9</italic> rs734553, <italic>ABCG2</italic> rs2231142, <italic>SLC17A</italic>1 rs1183201, <italic>SLC22A11</italic> rs17300741, <italic>SLC22A12</italic> rs505802, <italic>GCKR</italic> rs780094, <italic>PDZK1</italic> rs12129861, <italic>LRRC16A+SCGN</italic> rs742132, and <italic>SLC16A9</italic> rs12356193 in 1061 PD patients and 754 controls. For each subject we calculated a cumulative genetic risk score (GRS), defined as the total number of PD‐risk alleles (range, 2–15) associated to lower serum UA levels. Serum UA levels were measured in a subgroup of 365 PD cases and 132 controls.</p> </sec> <sec id="mds25507-sec-0003" sec-type="section"> <title>Results</title> <p>Serum UA levels were significantly lower in men with PD than in controls. Subjects (both men and women) carrying more than 9 risk alleles (third GRS tertile) had a 1.5 higher risk of developing PD than subjects with less than 8 risk alleles (first GRS tertile). An inverse correlation was observed between higher GRS and lower serum UA concentration in both men and women.</p> </sec> <sec id="mds25507-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Genetic variability influencing serum UA levels might modify susceptibility to PD. © 2013 International Parkinson and Movement Disorder Society</p> </sec> </abstract>