Questionnaire‐based diagnosis of REM sleep behavior disorder in Parkinson's disease. Issue 8 (20th March 2013)

• Record Type: Journal Article
• Authors: Chahine, Lama M.; Daley, Joseph; Horn, Stacy; Colcher, Amy; Hurtig, Howard; Cantor, Charles; Dahodwala, Nabila
• Is Part Of: Movement disorders. Volume 28:Issue 8(2013)
• Page Start: 1146
• Page End: 1149
• Publication Date: 2013-03-20
• Subjects: Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.25438
• Languages: English
• ISSNs: 0885-3185

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <sec id="mds25438-sec-0001" sec-type="section"> <title>Background</title> <p>Rapid eye movement (REM) sleep behavior disorder (RBD) is present in around 40% of Parkinson's disease (PD) patients. Definitive diagnosis requires a polysomnogram, but that is costly, time intensive, and not practical for large‐scale studies. Therefore, we assessed using a questionnaire‐based diagnostic approach.</p> </sec> <sec id="mds25438-sec-0002" sec-type="section"> <title>Methods</title> <p>The patient‐administered RBD questionnaire and bed‐partner‐administered question 1 of the Mayo questionnaire were prospectively validated.</p> </sec> <sec id="mds25438-sec-0003" sec-type="section"> <title>Results</title> <p>Seventy‐five PD patients (51 male, 68 Hoehn and Yahr stages I and II) participated. Forty‐eight had a clinical history of RBD. Sensitivity was 100% (95% CI, 86.3%–100%) when a combination of both questionnaires was compared with the gold standard of polysomnogram‐confirmed RBD. Among those who achieved REM sleep (n = 65), specificity was highest for the patient questionnaire used alone, at 82.4% (95% CI, 64.8%–92.6%).</p> </sec> <sec id="mds25438-sec-0004" sec-type="section"> <title>Conclusions</title> <p>A combination of patient and bed‐partner questionnaires is a useful tool to detect RBD. © 2013 <italic>Movement</italic> Disorder Society</p> </sec> </abstract>