Levodopa‐induced dyskinesias in tyrosine hydroxylase deficiency. Issue 8 (6th February 2013)

• Record Type: Journal Article
• Authors: Pons, Roser; Syrengelas, Dimitris; Youroukos, Sotiris; Orfanou, Irene; Dinopoulos, Arqirios; Cormand, Bru; Ormazabal, Aida; Garzía‐Cazorla, Angels; Serrano, Mercedes; Artuch, Rafael
• Is Part Of: Movement disorders. Volume 28:Issue 8(2013)
• Page Start: 1058
• Page End: 1063
• Publication Date: 2013-02-06
• Subjects: Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.25382
• Languages: English
• ISSNs: 0885-3185

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p>The objective of this study was to characterize levodopa (<sc>l‐</sc>dopa)–induced dyskinesias in patients with tyrosine hydroxylase deficiency. Clinical observation was carried out on 6 patients who were diagnosed with tyrosine hydroxylase deficiency and were treated with escalating doses of <sc>l‐</sc>dopa. All 6 patients showed <sc>l</sc>‐dopa‐induced dyskinesias of variable intensity early in the course of treatment and regardless of the age of initiation. <sc>l</sc>‐Dopa–induced dyskinesias were precipitated by increases in the dose of <sc>l</sc>‐dopa and also by febrile illnesses and stress. They caused dysfunction and distress in 2 patients. The dyskinesias were improved by decreasing the <sc>l</sc>‐dopa dose or by slowing its titration upward. Increasing the dose frequency was helpful in 2 patients, and introducing amantadine was helpful in another 2 patients. <sc>l</sc>‐Dopa–induced dyskinesias are a common phenomenon in tyrosine hydroxylase deficiency. The current observations show that <sc>l‐</sc>dopa–induced dyskinesias are frequent in a dopamine‐deficient state in the absence of nigrostriatal degeneration. Although <sc>l</sc>‐dopa–induced dyskinesias in tyrosine hydroxylase deficiency are phenomenologically similar to those that occur in Parkinson's disease, they are different in a number of other respects, suggesting intrinsic differences in the pathophysiologic basis of <sc>l‐</sc>dopa–induced dyskinesias in the 2 conditions. © 2013 <italic>Movement</italic> Disorder Society</p> </abstract>