Pilot study of H2 therapy in Parkinson's disease: A randomized double‐blind placebo‐controlled trial. Issue 6 (11th February 2013)

• Record Type: Journal Article
• Authors: Yoritaka, Asako; Takanashi, Masashi; Hirayama, Masaaki; Nakahara, Toshiki; Ohta, Shigeo; Hattori, Nobutaka
• Is Part Of: Movement disorders. Volume 28:Issue 6(2013)
• Page Start: 836
• Page End: 839
• Publication Date: 2013-02-11
• Subjects: Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.25375
• Languages: English
• ISSNs: 0885-3185

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mds25375-sec-0001" sec-type="section"> <title>Background</title> <p>Oxidative stress is involved in the progression of Parkinson's disease (PD). Recent studies have confirmed that molecular hydrogen (H<sub>2</sub>) functions as a highly effective antioxidant in cultured cells and animal models. Drinking H<sub>2</sub>‐dissolved water (H<sub>2</sub>‐water) reduced oxidative stress and improved Parkinson's features in model animals.</p> </sec> <sec id="mds25375-sec-0002" sec-type="section"> <title>Methods</title> <p>In this a placebo‐controlled, randomized, double‐blind, parallel‐group clinical pilot study, the authors assessed the efficacy of H<sub>2</sub>‐water in Japanese patients with levodopa‐medicated PD. Participants drank 1, 000 mL/day of H<sub>2</sub>‐water or pseudo water for 48 weeks.</p> </sec> <sec id="mds25375-sec-0003" sec-type="section"> <title>Results</title> <p>Total Unified Parkinson's Disease Rating Scale (UPDRS) scores in the H<sub>2</sub>‐water group (n=9) improved (median, −1.0; mean±standard deviation, −5.7±8.4), whereas UPDRS scores in the placebo group (n=8) worsened (median, 4.5; mean±standard deviation, 4.1±9.2). Despite the minimal number of patients and the short duration of the trial, the difference was significant (<italic>P</italic><0.05).</p> </sec> <sec id="mds25375-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The results indicated that drinking H<sub>2</sub>‐water was safe and well tolerated, and a significant improvement in total UPDRS scores for patients in the H<sub>2</sub>‐water group was demonstrated. © 2013 <italic>Movement</italic> Disorder Society</p> </sec> </abstract>