Enlarged hyperechogenic substantia nigra as a risk marker for Parkinson's disease. Issue 2 (31st October 2012)

• Record Type: Journal Article
• Authors: Berg, Daniela; Behnke, Stefanie; Seppi, Klaus; Godau, Jana; Lerche, Stefanie; Mahlknecht, Philipp; Liepelt‐Scarfone, Inga; Pausch, Christoph; Schneider, Niko; Gaenslen, Alexandra; Brockmann, Kathrin; Srulijes, Karin; Huber, Heiko; Wurster, Isabel; Stockner, Heike; Kiechl, Stefan; Willeit, Johann; Gasperi, Arno; Fassbender, Klaus; Gasser, Thomas; Poewe, Werner
• Is Part Of: Movement disorders. Volume 28:Issue 2(2013)
• Page Start: 216
• Page End: 219
• Publication Date: 2012-10-31
• Subjects: Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.25192
• Languages: English
• ISSNs: 0885-3185

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mds25192-sec-0001" sec-type="section"> <title>Background</title> <p>SN hyperechogenicity (SN+), determined by transcranial sonography, has been proposed as a risk factor for Parkinson's disease (PD). Recently, we reported a 17.4‐fold increased risk for PD in individuals with SN+ older than 50 years within 3 years.</p> </sec> <sec id="mds25192-sec-0002" sec-type="section"> <title>Methods</title> <p>This is the second follow‐up of a prospective, longitudinal, three‐center observational study after 5 years. Of the initial 1, 847 at baseline PD‐free participants 50 years or older, 1, 271 underwent the 5‐year reassessment.</p> </sec> <sec id="mds25192-sec-0003" sec-type="section"> <title>Results</title> <p>Within 5 years, 21 individuals developed incident PD. Participants with SN+ at baseline had a more than 20.6 times increased risk to develop PD in this time span than those without this echo feature.</p> </sec> <sec id="mds25192-sec-0004" sec-type="section"> <title>Conclusion</title> <p>We thus confirm our finding of the 3‐year follow‐up examination in a longer observation time and higher number of individuals with incident PD and suggest SN+ as an important risk marker for PD. © 2012 Movement Disorder Society</p> </sec> </abstract>