Systematic evaluation of bladder cancer risk‐associated single‐nucleotide polymorphisms in a chinese population. Issue 11 (18th June 2012)

• Record Type: Journal Article
• Authors: Ma, Zhicheng; Hu, Qingfeng; Chen, Zhuo; Tao, Sha; Macnamara, Lindsay; Kim, Seong‐Tae; Tian, Lu; Xu, Ke; Ding, Qiang; Zheng, Siqun L.; Sun, Jielin; Xia, Guowei; Xu, Jianfeng
• Is Part Of: Molecular carcinogenesis. Volume 52:Issue 11(2013:Nov.)
• Page Start: 916
• Page End: 921
• Publication Date: 2012-06-18
• Subjects: Carcinogenesis -- Molecular aspects -- Periodicals; 616.994071
• DOI: 10.1002/mc.21932
• Languages: English
• ISSNs: 0899-1987

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="mc21932-sec-0001" sec-type="section"> <p>Recently, genome‐wide association studies (GWAS) have identified over 12 single‐nucleotide polymorphisms (SNPs) associated with bladder cancer risk in populations of European descent. However, effects of these SNPs in bladder cancer have not been systemically evaluated in the Chinese population. We conducted association studies of 12 SNPs in a Chinese population of 184 cases and 962 controls. These SNPs were previously identified in European GWAS and a fine mapping study. The reported risk alleles of rs798766 on <italic>TACC3</italic> at 4p16 and rs9624880 on <italic>MYC</italic> at 8q24 were significantly associated with increased bladder cancer risk with <italic>P</italic>‐values of 0.003 and 0.03, respectively. Next, we performed a meta‐analysis, by combining our study with previous association studies performed in Chinese. In the meta‐analysis, the reported risk allele for four SNPs were significantly associated with increased bladder cancer risk, including rs798766 on <italic>TACC3</italic> at 4p16, rs9624880 on <italic>MYC</italic> at 8q24, rs2294008 on <italic>PSCA</italic> at 8q24, and rs2736100 on <italic>TERT</italic> at 5p15. The meta‐analysis <italic>P</italic>‐values for the four SNPs ranged from 0.017 to 5.52E−05. The results from our study suggest that a sub‐set of bladder cancer risk‐associated SNPs identified from the European population are also associated with bladder cancer risk in the Chinese population. Additional studies with larger sample sizes are needed to further confirm our results. © 2012 Wiley Periodicals, Inc.</p> </sec> </abstract>