Association of the miR‐146aC>G, miR‐149T>C, miR‐196a2T>C, and miR‐499A>G polymorphisms with gastric cancer risk and survival in the korean population. Issue 1 (21st September 2012)

• Record Type: Journal Article
• Authors: Ahn, Dae Ho; Rah, HyungChul; Choi, Young‐Kook; Jeon, Young Joo; Min, Kyung Tae; Kwack, KyuBum; Hong, Sung Pyo; Hwang, Seong Gyu; Kim, Nam Keun; Angel, Joe
• Is Part Of: Molecular carcinogenesis. Volume 52:Issue 1(2013:Jan.)
• Page Start: 39
• Page End: 51
• Publication Date: 2012-09-21
• Subjects: Carcinogenesis -- Molecular aspects -- Periodicals; 616.994071
• DOI: 10.1002/mc.21962
• Languages: English
• ISSNs: 0899-1987

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="mc21962-sec-0001" sec-type="section"> <p>We investigated whether four common microRNA polymorphisms (<italic>miR‐146a</italic>C>G [rs2910164], <italic>miR‐149</italic>T>C [rs2292832], <italic>miR‐196a2</italic>T>C [rs11614913], and <italic>miR‐499</italic>A>G [rs3746444]) are associated with the susceptibility and prognosis of gastric cancer in the Korean population. The four microRNA single‐nucleotide polymorphisms (SNPs) were identified in a case–control study (461 patients; 447 controls) by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) analysis in the Korean population. When patients were stratified into diffuse and intestinal‐type gastric cancer groups, subjects with the <italic>miR‐499</italic>AG and AG + GG genotypes had reduced adjusted odds ratios (AORs) for diffuse‐type gastric cancer (AOR = 0.54 with 95% confidence interval [CI] = 0.31–0.97; AOR = 0.57 with 95% CI = 0.33–0.97). In the stratified analyses for gastric cancer risk, the <italic>miR‐146a</italic>GG and CG + GG genotypes were associated with increased risk of gastric cancers among the non‐smokers, whereas the <italic>miR‐149</italic>TC and TC + CC genotypes showed lower risk of gastric cancer in males. The <italic>miR‐196a2</italic>CC genotype was associated with elevated gastric cancer risk among females. For gastric cancer prognosis, intestinal‐type gastric cancer patients with <italic>miR‐146a</italic>CG + GG genotypes had significantly higher survival rates (log‐rank <italic>P</italic> = 0.030) than patients with the CC genotype, and patients with the <italic>miR‐499</italic>AA genotype had significantly increased survival rates compared to patients with the AG + GG genotypes (log‐rank <italic>P</italic> = 0.013). When <italic>miR‐146a</italic>CG + GG and <italic>miR‐499</italic>AA genotypes were combined, the survival rate of intestinal‐type gastric cancer patients was elevated (log‐rank <italic>P</italic> < 0.001). No association was found between gastric or diffuse‐type cancer prognosis and other miRNAs. Our data demonstrate that specific miRNA SNPs are associated with gastric cancer susceptibility (<italic>miR‐499</italic>A>G) and prognosis (<italic>miR‐146a</italic>C>G and <italic>miR‐499</italic>A>G) in the Korean population depending on gastric cancer type. © 2012 Wiley Periodicals, Inc.</p> </sec> </abstract>