The polymorphisms and haplotypes of WWOX gene are associated with the risk of lung cancer in southern and eastern chinese populations. Issue 1 (12th June 2012)

• Record Type: Journal Article
• Authors: Huang, Dongsheng; Qiu, Fuman; Yang, Lei; Li, Yinyan; Cheng, Mei; Wang, Hui; Ma, Guanpei; Wang, Yunnan; Hu, Min; Ji, Weidong; Zhou, Yifeng; Lu, Jiachun; Angel, Joe
• Is Part Of: Molecular carcinogenesis. Volume 52:Issue 1(2013:Jan.)
• Page Start: 19
• Page End: 27
• Publication Date: 2012-06-12
• Subjects: Carcinogenesis -- Molecular aspects -- Periodicals; 616.994071
• DOI: 10.1002/mc.21934
• Languages: English
• ISSNs: 0899-1987

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="mc21934-sec-0001" sec-type="section"> <p>The WW domain‐containing oxidoreductase (<italic>WWOX</italic>) gene is an identified tumor suppressor gene, of which several single nucleotide polymorphisms have been reported to contribute to cancer susceptibility. We hypothesized that genetic variations in <italic>WWOX</italic> are associated with lung cancer risk. In two independent case–control studies conducted in southern and eastern Chinese, we genotyped five tagSNPs of <italic>WWOX</italic> gene (rs10220974C > T, rs3764340C > G, rs12918952G > A, rs383362G > T, and rs12828G > A) in 1, 559 lung cancer cases and 1, 679 controls. Logistic regression analysis showed that two tagSNPs (rs3764340C > G; rs383362G > T) were significantly associated with lung cancer risk in dominant model (rs3764340C > G, GC/GG vs. CC: adjust OR = 1.35, 95% CI = 1.11–1.65; rs383362G > T, TG + TT vs. GG: adjust OR = 1.33, 95% CI = 1.14–1.55). The haplotype analysis further shown that the haplotype "G‐T" was associated with the highest increased risk of lung cancer (OR = 2.20; 95% CI = 1.43–3.37). After combined these two loci, the number of the risk genotypes was associated with increased cancer risk in a dose–response manner (<italic>P</italic><sub>trend</sub> = 3.16 × 10<sup>−6</sup>). In addition, a gene‐based association analysis by using VEGAS software suggested the <italic>WWOX</italic> as a susceptible gene for lung cancer (<italic>P </italic>= 0.009). However, for rs10220974C > T, rs12918952G > A, and rs12828G > A, no significant association was observed for lung cancer risk. Taken together, our data suggested that genetic variants in <italic>WWOX</italic> may be genetic biomarkers for susceptibility to lung cancer. Copyright © 2012 Wiley Periodicals, Inc.</p> </sec> </abstract>