Effect of C60 Fullerene on the expression of ERN1 signaling related genes in human astrocytes. Issue 2 (13th March 2013)

• Record Type: Journal Article
• Authors: Minchenko, D.O.; Prylutska, S.V.; Moenner, M.; Minchenko, O.H.; Prylutskyy, Y.I.; Schütze, C.; Ritter, U.
• Is Part Of: Materialwissenschaft und Werkstofftechnik. Volume 44:Issue 2/3(2013)
• Page Start: 150
• Page End: 155
• Publication Date: 2013-03-13
• Subjects: Materials -- Periodicals; Materials -- Testing -- Periodicals; 620.1
• DOI: 10.1002/mawe.201300084
• Languages: English
• ISSNs: 0933-5137

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The effect of C₆₀ fullerene on the expression levels of genes, related to endoplasmic reticulum stress and cell proliferation, in human astrocytes was investigated. The exposure of human astrocytes to C₆₀ fullerene during 24 or 72 h increases the expression levels of transcription factor E2F8, insulin‐like growth factor binding protein‐2, and tumor suppressor SMAD mRNAs in human astrocytes. At the same time, the expression levels of HSD17B2, PBEF1, HSPB8 mRNA decrease in cells treated with C₆₀ fullerene, being more intense for HSD17B2. Moreover, C₆₀ fullerene increases the proliferation rate of astrocytes. Thus, C₆₀ fullerene affects the expression of genes which control proliferation.</p> </abstract>