Hydrolytically Degradable Thiol–ene Hydrogels for Protein Release. Issue 1 (23rd August 2013)

• Record Type: Journal Article
• Authors: Rehmann, Matthew S.; Garibian, Andrew C.; Kloxin, April M.; Bowman, Christopher N.; Horkay, Ferenc
• Is Part Of: Macromolecular symposia. Volume 329:Issue 1(2013)
• Page Start: 58
• Page End: 65
• Publication Date: 2013-08-23
• Subjects: Macromolecules -- Congresses; Polymers -- Congresses; Polymerization -- Congresses; Macromolecules -- Periodicals; Polymers -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1002/masy.201200133
• Languages: English
• ISSNs: 1022-1360

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Summary</title> <sec id="masy201200133-sec-0001" sec-type="section"> <p>A new degradable PEG‐diester‐dinorbornene/PEG‐triester‐trithiol hydrogel was evaluated for protein release. The hydrogel polymerized rapidly with seconds of UV irradiation and subsequently hydrolytically degraded in aqueous buffer over the course of approximately 3 weeks. Further, the hydrogel enabled the encapsulation and release of a model protein, bovine serum albumin (BSA), over 7 days with ∼ 90% released at 48 h. This study serves as a proof‐of‐concept for the creation of hydrolytically degradable, PEG‐ester‐thiol‐based hydrogels by a photoinitiated step growth mechanism for protein release. With this approach, degradation and release rates could be tuned by varying the monomer molecular weight and functionality in future studies.</p> </sec> </abstract>