Biodegradable Coumaric Acid‐Based Poly(anhydride‐ester) Synthesis and Subsequent Controlled Release. Issue 15 (9th July 2013)

• Record Type: Journal Article
• Authors: Ouimet, Michelle A.; Stebbins, Nicholas D.; Uhrich, Kathryn E.
• Is Part Of: Macromolecular rapid communications. Volume 34:Issue 15(2013:Aug.)
• Page Start: 1231
• Page End: 1236
• Publication Date: 2013-07-09
• Subjects: Macromolecules -- Periodicals; Polymers -- Periodicals; Chemistry -- Periodicals; 547.705
• DOI: 10.1002/marc.201300323
• Languages: English
• ISSNs: 1022-1336

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>To overcome drug delivery issues associated with its short half‐life in vivo, <italic>p</italic>‐coumaric acid (pCA), a naturally occurring bioactive, has been chemically incorporated into a poly(anhydride‐ester) backbone through solution polymerization. Nuclear magnetic resonance and Fourier transform infrared spectroscopies indicated that pCA was successfully incorporated without noticeable alterations in structural integrity. The polymer's weight‐average molecular weight and thermal properties were determined, exhibiting a molecular weight of over 26 000 Da and a glass transition temperature of 57 °C. In addition, in vitro hydrolytic release studies demonstrated pCA release over 30 d with maintained antioxidant activity, demonstrating the polymer's potential as a controlled release system. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg37fg3qgc" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>