Controlled Microstructuring of Janus Particles Based on a Multifunctional Poly(ethylene glycol). Issue 19 (28th August 2013)

• Record Type: Journal Article
• Authors: Sokolovskaya, Ekaterina; Yoon, Jaewon; Misra, Asish C.; Bräse, Stefan; Lahann, Jörg
• Is Part Of: Macromolecular rapid communications. Volume 34:Issue 19(2013:Oct.)
• Page Start: 1554
• Page End: 1559
• Publication Date: 2013-08-28
• Subjects: Macromolecules -- Periodicals; Polymers -- Periodicals; Chemistry -- Periodicals; 547.705
• DOI: 10.1002/marc.201300427
• Languages: English
• ISSNs: 1022-1336

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>A novel water insoluble, multifunctional poly(ethylene glycol), poly(hydrazide ethylene glycol‐<italic>co</italic>‐benzyl glycidyl ether) (P(HZ‐<italic>co</italic>‐BnGE)), is synthesized via thiol‐ene click reaction of poly(allyl glycidyl ether‐<italic>co</italic>‐benzyl glycidyl ether) (P(AGE‐<italic>co</italic>‐BnGE)). The base polymer P(AGE‐<italic>co</italic>‐BnGE) is previously prepared by anionic ring‐opening copolymerization of the corresponding monomers. To demonstrate utility, bicompartmental microspheres and microcylinders containing P(HZ‐<italic>co</italic>‐BnGE) in one of the compartments are prepared via electrohydrodynamic (EHD) co‐jetting. Next, spatially controlled surface reactivity toward sugars is demonstrated by selective binding of 2α‐mannobiose to the P(HZ‐<italic>co</italic>‐BnGE) compartment only, as confirmed by a carbohydrate‐lectin‐binding assay. These sugar‐reactive hydrazide‐presenting microparticles have potential applications for glyco‐targeted drug delivery. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg3j28s4z4" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>