Facile Synthesis of Multicompartment Micelles Based on Biocompatible Poly(3‐hydroxyalkanoate). Issue 4 (12th December 2012)

• Record Type: Journal Article
• Authors: Babinot, Julien; Renard, Estelle; Le Droumaguet, Benjamin; Guigner, Jean‐Michel; Mura, Simona; Nicolas, Julien; Couvreur, Patrick; Langlois, Valérie
• Is Part Of: Macromolecular rapid communications. Volume 34:Issue 4(2013:Feb.)
• Page Start: 362
• Page End: 368
• Publication Date: 2012-12-12
• Subjects: Macromolecules -- Periodicals; Polymers -- Periodicals; Chemistry -- Periodicals; 547.705
• DOI: 10.1002/marc.201200692
• Languages: English
• ISSNs: 1022-1336

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>In this paper, a straightforward method to produce poly(3‐hydroxyalkanoate)‐based multicompartment micelles (MCMs) is presented. Thiol‐ene addition is used to graft sequentially perfluorooctyl chains and poly(ethylene glycol) oligomers onto poly(3‐hydroxyoctanoate‐<italic>co</italic>‐hydroxyundecenoate) oligomers backbone. Well‐defined copolymers are obtained as shown by ¹H NMR and size‐exclusion chromatography. After nanoprecipitation in water, novel PHA‐based MCMs are evidenced by cryo‐transmission electron microscopy. Moreover, the cytocompatibility of MCMs is demonstrated in vitro via cell viability assay.</p> </abstract>