Characterization of Thiol‐Ene Crosslinked PEG Hydrogels. Issue 6 (19th September 2012)

• Record Type: Journal Article
• Authors: Toepke, Michael W.; Impellitteri, Nicholas A.; Theisen, Jeffrey M.; Murphy, William L.
• Is Part Of: Macromolecular materials and engineering. Volume 298:Issue 6(2013:Jun.)
• Page Start: 699
• Page End: 703
• Publication Date: 2012-09-19
• Subjects: Plastics -- Periodicals; Polymers -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1002/mame.201200119
• Languages: English
• ISSNs: 1438-7492

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The properties of synthetic hydrogels can be tuned to address the needs of many tissue‐culture applications. This work characterizes the swelling and mechanical properties of thiol‐ene crosslinked PEG hydrogels made with varying prepolymer formulations, demonstrating that hydrogels with a compressive modulus exceeding 600 kPa can be formed. The amount of peptide incorporated into the hydrogel is shown to be proportional to the amount of peptide in the prepolymer solution. Cell attachment and spreading on the surface of the peptide‐functionalized hydrogels is demonstrated. Additionally, a method for bonding distinct layers of cured hydrogels is used to create a microfluidic channel. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg21mh4sf7" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>