Disulfide Cross‐Linked Polypeptide Nanogel Conjugated with a Fluorescent Probe as a Potential Image‐Guided Drug‐Delivery Agent. Issue 5 (13th December 2012)

• Record Type: Journal Article
• Authors: Xing, Tao; Lai, Bin; Yan, Lifeng
• Is Part Of: Macromolecular chemistry and physics. Volume 214:Issue 5(2013:Mar.)
• Page Start: 578
• Page End: 588
• Publication Date: 2012-12-13
• Subjects: Polymers -- Periodicals; Polymerization -- Periodicals; Synthetic products -- Periodicals; Macromolecules -- Periodicals; 547.7
• DOI: 10.1002/macp.201200568
• Languages: English
• ISSNs: 1022-1352

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A disulfide cross‐linked PEGylated polypeptide nanogel with a near infrared fluorescence (NIRF) group has been synthesized. At first, a NIRF nanogel precursor is prepared by a ring‐opening polymerization of <sc>L</sc>‐cystine‐<italic>N</italic>‐carboxy anhydride with azide‐functionalized poly(ethylene glycol) methyl ether. Alkyne cyanine is then conjugated to the nanogel by a click chemical reaction. The formation of the targeted nanogel is confirmed by a series of characterizations. The anticancer drug doxorubicin can be loaded into the NIRF nanogel by physical encapsulation, and the obtained drug‐loaded NIRF nanoparticle shows reduction‐promoted drug‐release behavior in the presence of 10 mM glutathione. The as‐prepared drug‐loaded NIRF nanoparticle has potential applications in the real‐time imaging of drug delivery in vivo.</p> </abstract>