A prospective pilot study to evaluate combined topical photodynamic therapy and surgery for extramammary paget's disease. Issue 5 (5th June 2013)

• Record Type: Journal Article
• Authors: Wang, Hong‐wei; Lv, Ting; Zhang, Ling‐lin; Lai, Yong‐xian; Tang, Li; Tang, Yi‐chen; Huang, Zheng; Wang, Xiu‐li
• Is Part Of: Lasers in surgery and medicine. Volume 45:Issue 5(2013)
• Page Start: 296
• Page End: 301
• Publication Date: 2013-06-05
• Subjects: Lasers in medicine -- Periodicals; Lasers in surgery -- Periodicals; 617
• DOI: 10.1002/lsm.22142
• Languages: English
• ISSNs: 0196-8092

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="lsm22142-sec-0001" sec-type="section"> <title>Background and objective</title> <p>Extramammary Paget's disease (EMPD) is a rare intra‐epithelial neoplasm. Surgical excision is the treatment of choice. The usefulness of topical photodynamic therapy (PDT) in the treatment of EMPD has been reported. The objective of this prospective pilot study was to investigate the feasibility of combined PDT and surgery in the treatment of EMPD.</p> </sec> <sec id="lsm22142-sec-0002" sec-type="section"> <title>Subjects and Methods</title> <p>A total of 13 patients with 19 large EMPD lesions were recruited and assigned to surgery (<italic>n</italic> = 5) or PDT + surgery (<italic>n</italic> = 8) group. For the PDT + surgery group, four sessions of topical PDT mediated with 20% 5‐aminolevulinic acid (ALA‐PDT) were applied prior to surgery. Patients were followed up for 12 months. Treatment outcomes, adverse reactions and recurrence were compared.</p> </sec> <sec id="lsm22142-sec-0003" sec-type="section"> <title>Results</title> <p>In the surgery group, recurrence was seen in 2 out of 8 lesions (25%). In the combination group, over 58% reduction in lesion size was achieved after 4‐sessions of PDT and recurrence was seen in 1 out of 11 lesions (9.1%) after surgery.</p> </sec> <sec id="lsm22142-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Multiple ALA‐PDT could be applied to reduce the severity of EMPD lesion and improve the success of surgery. Lasers Surg. Med. 45:296–301, 2013. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>