Preparative enantioseparation of propafenone by counter‐current chromatography using di‐n‐butyl l‐tartrate combined with boric acid as the chiral selector. Issue 18 (6th August 2013)

• Record Type: Journal Article
• Authors: Tong, Shengqiang; Shen, Mangmang; Zheng, Ye; Chu, Chu; Li, Xing‐Nuo; Yan, Jizhong
• Is Part Of: Journal of separation science. Volume 36:Issue 18(2013:Sep.)
• Page Start: 3101
• Page End: 3106
• Publication Date: 2013-08-06
• Subjects: Separation (Technology) -- Periodicals; Chromatographic analysis -- Periodicals; 543.089
• DOI: 10.1002/jssc.201300614
• Languages: English
• ISSNs: 1615-9306

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>This paper extends the research of the utilization of borate coordination complexes in chiral separation by counter‐current chromatography (CCC). Racemic propafenone was successfully enantioseparated by CCC with di‐<italic>n</italic>‐butyl <sc>l</sc>‐tartrate combined with boric acid as the chiral selector. The two‐phase solvent system was composed of chloroform/ 0.05 mol/L acetate buffer pH 3.4 containing 0.10 mol/L boric acid (1:1, v/v), in which 0.10 mol/L di‐<italic>n</italic>‐butyl <sc>l</sc>‐tartrate was added in the organic phase. The influence of factors in the enantioseparation of propafenone were investigated and optimized. A total of 92 mg of racemic propafenone was completely enantioseparated using high‐speed CCC in a single run, yielding 40–42 mg of (<italic>R</italic>)‐ and (<italic>S</italic>)‐propafenone enantiomers with an HPLC purity over 90–95%. The recovery for propafenone enantiomers from fractions of CCC was in the range of 85–90%.</p> </abstract>