Does long‐term survival in patients with pancreatic cancer really exist?—Results from the CONKO‐001 study. Issue 6 (23rd August 2013)

• Record Type: Journal Article
• Authors: Sinn, Marianne; Striefler, Jana K.; Sinn, Bruno V.; Sallmon, Daniel; Bischoff, Sven; Stieler, Jens M.; Pelzer, Uwe; Bahra, Marcus; Neuhaus, Peter; Dörken, Bernd; Denkert, Carsten; Riess, Hanno; Oettle, Helmut
• Is Part Of: Journal of surgical oncology. Volume 108:Issue 6(2013:Nov. 01)
• Page Start: 398
• Page End: 402
• Publication Date: 2013-08-23
• Subjects: Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.23409
• Languages: English
• ISSNs: 0022-4790

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="jso23409-sec-0001" sec-type="section"> <title>Background</title> <p>Long‐term survival (LTS) in patients (pts) with pancreatic cancer is still uncommon, little data is available to identify long‐term survivors. The CONKO‐001 study, which established gemcitabine after resection as adjuvant therapy, may provide data to answer this question.</p> </sec> <sec id="jso23409-sec-0002" sec-type="section"> <title>Methods</title> <p>CONKO‐001 pts with an overall survival ≥5 years were compared to those who survived <5 years. Central re‐evaluation of primary histology was performed. Univariate analysis with the <italic>χ</italic><sup>2</sup>‐test identified qualifying factors. Logistic regression was used to investigate the influence of these covariates on LTS.</p> </sec> <sec id="jso23409-sec-0003" sec-type="section"> <title>Results</title> <p>Of the evaluable 354 CONKO‐001 pts, 54 (15%) with an overall survival ≥5 years were identified. It was possible to obtain tumor specimens of 39 pts (72%). Histological re‐evaluation confirmed adenocarcinoma in 38 pts, 1 showed a high‐grade neuroendocrine tumor. Univariate analysis for all 53 LTS pts with adenocarcinoma compared to the remaining 300 non‐LTS pts revealed as relevant active treatment, tumor grading, tumor size, lymph nodes. No significance could be demonstrated for resection margin, sex, age, Karnofsky performance status, CA 19‐9 at study entry. In multivariate analysis, tumor grading, active treatment, tumor size, lymph node involvement were independent prognostic factors for LTS.</p> </sec> <sec id="jso23409-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Long‐term survival can be achieved in adenocarcinoma of the pancreas. <italic>J. Surg. Oncol. 2013; 108:398–402</italic>. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>