Surgery for Metastasis to the Pancreas: Is it Safe and Effective?. Issue 8 (1st May 2013)

• Record Type: Journal Article
• Authors: Niess, Hanno; Conrad, Claudius; Kleespies, Axel; Haas, Florian; Bao, Qi; Jauch, Karl‐Walter; Graeb, Christian; Bruns, Christiane J.
• Is Part Of: Journal of surgical oncology. Volume 107:Issue 8(2013:Jun. 15)
• Page Start: 859
• Page End: 864
• Publication Date: 2013-05-01
• Subjects: Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.23333
• Languages: English
• ISSNs: 0022-4790

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Background</title> <p>Pancreatic metastases are rare and only sparse data exists on treatment options. After recent advances in pancreatic surgery, metastasectomies have become promising treatment alternatives.</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Methods</title> <p>Twenty‐six patients underwent pancreatic metastasectomy between 1991 and 2010 at our institution. Data was evaluated retrospectively.</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Results</title> <p>Renal cell carcinoma was the most common origin of pancreatic metastases (n = 16; 62%). Other primaries include gall bladder carcinoma, leiomyosarcoma, colon cancer (all n = 2), and others. The median time interval between primary tumor and pancreatic resection was 5.3 years [0–24]. Eleven pancreatic head resections (42%), fourteen distal pancreatectomies (54%), and one total pancreatectomy were performed (4%). The estimated 3‐ and 5‐year survival rates were 73.2% and 52.3%, respectively. The estimated median overall survival was 63 months (CI: 37.8–88.1 months). There' was no perioperative death. The complication rate and relaparotomy rate was 31% and 19%, respectively. Patients suffering from synchronous metastases at the time of pancreatic surgery had a statistically significant shorter median overall survival time (11 months vs. 64 months).</p> </sec> <sec id="abs1-4" sec-type="section"> <title>Conclusions</title> <p>Despite the operative risk involved, we believe that pancreatic resection should be considered in selected patients with good performance status, stable disease and isolated pancreatic metastases. J. Surg. Oncol. 2013;107:859–864. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>