Prognostic value of the D‐dimer test in oesophageal cancer during the perioperative period. Issue 1 (15th May 2013)

• Record Type: Journal Article
• Authors: Diao, Dongmei; Zhu, Kun; Wang, Zhe; Cheng, Yao; Li, Kang; Pei, Leilei; Dang, Chengxue
• Is Part Of: Journal of surgical oncology. Volume 108:Issue 1(2013:Jul. 01)
• Page Start: 34
• Page End: 41
• Publication Date: 2013-05-15
• Subjects: Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.23339
• Languages: English
• ISSNs: 0022-4790

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="jso23339-sec-0001" sec-type="section"> <title>Background</title> <p>There has been little research on the perioperative D‐dimer levels in oesophageal cancer patients. Plasma D‐dimer levels can be used to predict the outcome in cancer patients.</p> </sec> <sec id="jso23339-sec-0002" sec-type="section"> <title>Methods</title> <p>A cancer group of 66 oesophageal cancer patients and a control group of 12 patients with benign disease were enrolled in this cohort study. The plasma D‐dimer levels during the pre‐operation and 3rd and 9th day post‐operation periods were prospectively examined and analysed between the two groups. Plasma D‐dimer levels were also compared with the clinicopathological characteristics and 3‐year survival of the oesophageal cancer patients.</p> </sec> <sec id="jso23339-sec-0003" sec-type="section"> <title>Results</title> <p>Plasma D‐dimer levels increased in both groups after surgery, but they were significantly higher in the cancer group. In oesophageal cancer patients, pre‐operation plasma D‐dimer levels were significantly higher in TNM stage IV patients. Perioperative plasma D‐dimer levels significantly increased after surgery, and the survival was shortened in those patients whose D‐dimer levels on the 3rd and 9th post‐operative day above the median. In addition, increased plasma D‐dimer levels at the 3rd and 9th days after surgery were influenced by the patient's age.</p> </sec> <sec id="jso23339-sec-0004" sec-type="section"> <title>Conclusion</title> <p>In oesophageal cancer patients, D‐dimer levels increased after surgery, and the increases were associated with poor outcomes. <italic>J. Surg. Oncol. 2013 108:34–41</italic>. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>