Indicators of symptom improvement and survival in inpatients with advanced cancer undergoing palliative surgical consultation. Issue 4 (6th August 2012)

• Record Type: Journal Article
• Authors: Badgwell, Brian D.; Aloia, Thomas A.; Garrett, John; Chedister, Gabe; Miner, Tom; Krouse, Robert
• Is Part Of: Journal of surgical oncology. Volume 107:Issue 4(2013:Mar. 15)
• Page Start: 367
• Page End: 371
• Publication Date: 2012-08-06
• Subjects: Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.23236
• Languages: English
• ISSNs: 0022-4790

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Background</title> <p>The purpose of this study was to prospectively identify the presentation, treatment, and outcomes of inpatients with advanced malignancy undergoing palliative surgical consultation.</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Methods</title> <p>Inpatients undergoing palliative surgical consultation were prospectively identified from November 2008 to May 2011. Medical records were retrospectively reviewed to obtain clinical data and outcome.</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Results</title> <p>Of 202 consultations, the diagnoses were wound problems (N = 39, 19%), bowel obstruction (N = 75, 37%), intra‐abdominal inflammatory conditions (N = 36, 18%), abdominal pain of unclear etiology (N = 13, 6%), gastrointestinal hemorrhage (N = 15, 7%), malnutrition/feeding tube request (N = 14, 7%), and biliary obstruction (N = 10, 5%). Management included non‐operative/non‐procedural treatment in 81 (40%), procedures in 35 (17%), and surgery in 86 (43%). Patients treated with non‐operative/non‐procedural, procedural, and surgical treatment demonstrated symptom improvement rates of 60% (49/81), 69% (24/35), and 78% (67/86), respectively. Surgical treatment was associated with symptom improvement (OR 2.3 [95% CI 1.2–4.5]) compared to non‐operative/non‐procedural management. Symptom improvement was associated with improved survival (HR 0.27 [95% CI 0.19–0.38]) on multivariate analysis.</p> </sec> <sec id="abs1-4" sec-type="section"> <title>Conclusions</title> <p>Symptom improvement was obtained in the majority of patients regardless of treatment strategy. Although patients selected for surgery demonstrated an association with symptom improvement, future prospective studies are needed to determine additional variables important in treatment selection. J. Surg. Oncol. 2013;107:367–371. © 2012 Wiley Periodicals, Inc.</p> </sec> </abstract>