Resection of large hepatocellular carcinoma (≥10 cm): A unique western perspective. Issue 2 (17th August 2012)

• Record Type: Journal Article
• Authors: Shrager, Brian; Jibara, Ghalib A.; Tabrizian, Parissa; Schwartz, Myron E.; Labow, Daniel M.; Hiotis, Spiros
• Is Part Of: Journal of surgical oncology. Volume 107:Issue 2(2013:Feb. 01)
• Page Start: 111
• Page End: 117
• Publication Date: 2012-08-17
• Subjects: Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.23246
• Languages: English
• ISSNs: 0022-4790

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Background and Objectives</title> <p>Few Western centers have surgically treated a high volume of large hepatocellular carcinoma 10 cm or more in diameter. The study aim was to analyze a large Western cohort of these patients, and to present our outcomes in the context of the more extensive Eastern experience.</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Methods</title> <p>We retrospectively reviewed all patients at our center receiving partial hepatectomy from January 1992 to August 2010, and analyzed a cohort with hepatocellular carcinoma ≥10 cm in diameter.</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Results</title> <p>One hundred thirty patients comprised the cohort. One hundred three (79.2%) of the patients received major anatomic resections, and 23 (17.7%) patients underwent tumor thrombectomy as an adjunct procedure. Perioperative mortality was observed in 9 (6.9%) of cases, but from January 2002 onward, only 2 (2.3%) of the 86 resections performed resulted in a mortality. The survival rate at 1, 3, and 5 years was 56.9%, 30.3%, and 18.8%, respectively; the median survival was 17.0 months. The subgroup of 39 patients <italic>without</italic> gross vascular invasion and satellite nodules achieved a median survival of 40.3 months.</p> </sec> <sec id="abs1-4" sec-type="section"> <title>Conclusions</title> <p>Resection of large hepatocellular carcinoma can be done with safety at a large Western center, and a subgroup of patients will achieve long‐term survival. J. Surg. Oncol. 2013;107:111–117. © 2012 Wiley Periodicals, Inc.</p> </sec> </abstract>