Treatment‐related morbidity and toxicity of CRS and oxaliplatin‐based HIPEC compared to a mitomycin and doxorubicin‐based HIPEC protocol in patients with peritoneal carcinomatosis: A matched‐pair analysis. Issue 6 (25th July 2012)

• Record Type: Journal Article
• Authors: Glockzin, Gabriel; von Breitenbuch, Philipp; Schlitt, Hans J.; Piso, Pompiliu
• Is Part Of: Journal of surgical oncology. Volume 107:Issue 6(2013:May 01)
• Page Start: 574
• Page End: 578
• Publication Date: 2012-07-25
• Subjects: Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.23228
• Languages: English
• ISSNs: 0022-4790

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Introduction</title> <p>Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provide a promising therapeutic option for selected patients with peritoneal carcinomatosis. The use of intraperitoneal oxaliplatin seems to further improve the efficacy of the combined treatment concept. Nevertheless, additional toxicity might be expected.</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Patients and Methods</title> <p>Between 03/2004 and 08/2010 307 patients underwent CRS and HIPEC at the University Medical Center Regensburg. Forty of these patients received oxaliplatin‐based HIPEC. A matched‐pair analysis was performed to compare IP oxaliplatin to our former standard HIPEC protocol with mitomycin C (MMC) and doxorubicin.</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Results</title> <p>The mean operating time in the OX and the MMC group was 315 and 313 min, respectively. Median hospital stay was 15.5 days in the OX group and 17 days in the MMC group. The grade 3/4 morbidity rate according to CTCAEv3.0 was 42.5% versus 37.5% (<italic>P</italic> = 0.648). Perioperative mortality was 2.5% versus 0%.</p> </sec> <sec id="abs1-4" sec-type="section"> <title>Conclusion</title> <p>Our data suggest that the use of IP oxaliplatin in the context of CRS and HIPEC does not significantly increase perioperative morbidity and/or mortality rates. Nevertheless, randomized controlled trials are required to determine the optimal intraperitoneal chemotherapeutic regimen regarding toxicity, postoperative complications, and oncological outcome. J. Surg. Oncol. 2013;107:574–578. © 2012 Wiley Periodicals, Inc.</p> </sec> </abstract>