Investigation of clinical pharmacokinetic variability of an opioid antagonist through physiologically based absorption modeling. Issue 8 (11th June 2013)

• Record Type: Journal Article
• Authors: Ding, Xuan; He, Minxia; Kulkarni, Rajesh; Patel, Nita; Zhang, Xiaoyu
• Is Part Of: Journal of pharmaceutical sciences. Volume 102:Issue 8(2013:Aug.)
• Page Start: 2859
• Page End: 2874
• Publication Date: 2013-06-11
• Subjects: Pharmacy -- Periodicals; 615.1
• DOI: 10.1002/jps.23629
• Languages: English
• ISSNs: 0022-3549

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Identifying the source of inter‐ and/or intrasubject variability in pharmacokinetics (PK) provides fundamental information in understanding the pharmacokinetics–pharmacodynamics relationship of a drug and project its efficacy and safety in clinical populations. This identification process can be challenging given that a large number of potential causes could lead to PK variability. Here we present an integrated approach of physiologically based absorption modeling to investigate the root cause of unexpectedly high PK variability of a Phase I clinical trial drug. LY2196044 exhibited high intersubject variability in the absorption phase of plasma concentration–time profiles in humans. This could not be explained by <italic>in vitro</italic> measurements of drug properties and excellent bioavailability with low variability observed in preclinical species. GastroPlus™ modeling suggested that the compound's optimal solubility and permeability characteristics would enable rapid and complete absorption in preclinical species and in humans. However, simulations of human plasma concentration–time profiles indicated that despite sufficient solubility and rapid dissolution of LY2196044 in humans, permeability and/or transit in the gastrointestinal (GI) tract may have been negatively affected. It was concluded that clinical PK variability was potentially due to the drug's antagonism on opioid receptors that affected its transit and absorption in the GI tract. © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 102:2859–2874, 2013</p> </abstract>