Nanovesicles system for rapid‐onset sublingual delivery containing sodium tanshinone IIA sulfonate: In vitro and in vivo evaluation. Issue 7 (23rd April 2013)

• Record Type: Journal Article
• Authors: Zhu, Hongda; Hao, Jianjun; Chen, Huabing; Jiang, Shanshan; Liu, Mingxing; Sun, Honghao; Xu, Huibi; Zhang, Jiemei; Yang, Xiangliang
• Is Part Of: Journal of pharmaceutical sciences. Volume 102:Issue 7(2013:Jul.)
• Page Start: 2332
• Page End: 2340
• Publication Date: 2013-04-23
• Subjects: Pharmacy -- Periodicals; 615.1
• DOI: 10.1002/jps.23512
• Languages: English
• ISSNs: 0022-3549

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A novel formulation based on nanovesicles system for rapid‐onset sublingual delivery of hydrophilic drug (sodium tanshinone IIA sulfonate, STS) was investigated. The nanovesicles system was composed of 1.5% soybean lecithin, 6% propylene glycol, and penetration enhancers (1% sodium dodecyl sulfate and 0.03% hyaluronan acid). The STS‐loaded nanovesicles with an average diameter of 133 ± 9.04 nm and high entrapment efficiency of 85.65 ± 3.89% were characterized. The effects of permeation enhancers on the penetration of STS formulations were investigated using Franz diffusion cells <italic>in vitro</italic>, showing 86.1–235.8 times higher permeation rate than that of normal STS solution. The rapid symptom relief effect of the nanovesicles system on acute myocardial infarction rabbits was evaluated by <italic>in vivo</italic> study, ST‐segment deviation(S and T wave abnormality in electrocardiogram) was attenuated markedly and rapidly within 5 min, infarct size of heart was significantly reduced and the biochemical indicators were substantially decreased, compared with the control groups (<italic>p</italic> &lt; 0.05). This study provided a promising tool for the future sublingual delivery of hydrophilic compounds with the noninvasive and rapid onset clinical effect. © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 102:2332–2340, 2013</p> </abstract>