Late gadolinium enhancement in the assessment of the infarcted mouse heart: A longitudinal comparison with manganese‐enhanced MRI. Issue 6 (4th April 2013)

• Record Type: Journal Article
• Authors: Skårdal, Kristine; Rolim, Natale P.L.; Haraldseth, Olav; Goa, Pål Erik; Thuen, Marte
• Is Part Of: Journal of magnetic resonance imaging. Volume 38:Issue 6(2013)
• Page Start: 1388
• Page End: 1394
• Publication Date: 2013-04-04
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24127
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24127-sec-0001" sec-type="section"> <title>Purpose</title> <p>To evaluate late gadolinium‐enhanced (LGE) assessment of infarct size, a comparison with manganese‐enhanced magnetic resonance imaging (MEMRI), and histology was performed in a permanent infarction model in the mouse at the acute and chronic stage.</p> </sec> <sec id="jmri24127-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>In a paired fashion at the acute and chronic stage after infarction (3–4 days and 21 days, respectively), LGE and MEMRI was performed using a self‐gated fast low flip angle shot (FLASH). Infarct size was evaluated as the enhanced area relative to the complete myocardial wall area in a mid‐ventricular slice. Paired comparisons were made between contrast agents and between timepoints, as well as to histology.</p> </sec> <sec id="jmri24127-sec-0003" sec-type="section"> <title>Results</title> <p>At the acute stage, LGE delineated a larger infarct size as compared to both MEMRI and histology. Infarct size from LGE decreased from the acute to chronic stage, a temporal development not seen with MEMRI. At the chronic stage, no significant differences in infarct size were found between the methods.</p> </sec> <sec id="jmri24127-sec-0004" sec-type="section"> <title>Conclusion</title> <p>This study indicates an overenhancement of infarct size when using LGE, supported by an initial overestimation at the acute stage and a temporal decrease in infarct size from the acute to chronic stage, as compared to infarct size from MEMRI. J. Magn. Reson. Imaging 2013;38:1388–1394. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>