Cerebral blood flow quantification in swine using pseudo‐continuous arterial spin labeling. Issue 5 (16th September 2013)

• Record Type: Journal Article
• Authors: Johnston, Megan E.; Zheng, Zhenlin; Maldjian, Joseph A.; Whitlow, Christopher T.; Morykwas, Michael J.; Jung, Youngkyoo
• Is Part Of: Journal of magnetic resonance imaging. Volume 38:Issue 5(2013)
• Page Start: 1111
• Page End: 1118
• Publication Date: 2013-09-16
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24066
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24066-sec-0001" sec-type="section"> <title>Purpose</title> <p>To develop quantitative cerebral blood flow (CBF) imaging using pseudo‐continuous arterial spin labeling (PCASL) in swine, accounting for their cerebrovascular anatomy and physiology.</p> </sec> <sec id="jmri24066-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>Five domestic pigs (2.5–3 months, 25 kg) were used in these studies. The orientation of the labeled arteries, T<sub>1bl</sub>, M<sub>0bl</sub>, and T<sub>1gm</sub> were measured in swine. Labeling parameters were tuned with respect to blood velocity to optimize labeling efficiency based on the data collected from three subjects. Finally, CBF and arterial transit time (ATT) maps for two subjects were created from PCASL data to determine global averages.</p> </sec> <sec id="jmri24066-sec-0003" sec-type="section"> <title>Results</title> <p>The average labeling efficiency over measured velocities of 5–18 cm/s was 0.930. The average T<sub>1bl</sub> was 1546 ms, the average T<sub>1gm</sub> was 1224 ms, and the average blood‐to‐white matter ratio of M<sub>0</sub> was 1.25, which was used to find M<sub>0bl</sub>. The global averages over the subjects were 54.05 mL/100 g tissue/min CBF and 1261 ms ATT.</p> </sec> <sec id="jmri24066-sec-0004" sec-type="section"> <title>Conclusion</title> <p>This study demonstrates the feasibility of PCASL for CBF quantification in swine. Quantification of CBF using PCASL in swine can be further developed as an accessible and cost‐effective model of human cerebral perfusion for investigating injuries that affect blood flow. J. Magn. Reson. Imaging 2013;38:1111–1118. © 2012 Wiley Periodicals, Inc.</p> </sec> </abstract>