High temporal resolution 3D gadolinium‐enhanced dynamic MR imaging of renal tumors with pharmacokinetic modeling: Preliminary observations. Issue 4 (6th February 2013)

• Record Type: Journal Article
• Authors: Chandarana, Hersh; Amarosa, Alana; Huang, William C.; Kang, Stella K.; Taneja, Samir; Melamed, Jonathan; Kim, Sungheon
• Is Part Of: Journal of magnetic resonance imaging. Volume 38:Issue 4(2013)
• Page Start: 802
• Page End: 808
• Publication Date: 2013-02-06
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24035
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24035-sec-0001" sec-type="section"> <title>Purpose</title> <p>To assess dynamic contrast‐enhanced (DCE) magnetic resonance imaging (MRI) tracer pharmacokinetic parameters obtained with Generalized Kinetic Model (GKM) and extended Shutter Speed Model (SSM2) in renal tumors stratified by histologic subtypes.</p> </sec> <sec id="jmri24035-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>In all, 24 patients with renal tumors were imaged at 1.5 T utilizing DCE‐MRI with high temporal resolution (1.2 sec/temporal frame) prior to surgery. Tracer kinetic analysis was performed for the entire tumor using individualized aortic input function. GKM and SSM2 were employed to generate transfer constant (<italic>K</italic><sup><italic>trans</italic></sup>), plasma volume, and interstitial volume. These parameters, and Δ<italic>K</italic><sup><italic>trans</italic></sup> (<italic>K</italic><sup><italic>trans</italic></sup>SSM2 − <italic>K</italic><sup><italic>trans</italic></sup>GKM) were compared between tumors stratified by histologic subtype.</p> </sec> <sec id="jmri24035-sec-0003" sec-type="section"> <title>Results</title> <p>There were 25 renal tumors: 15 clear cell, 4 papillary, 3 chromophobe, and 3 oncocytoma/oncocytic subtype. <italic>K</italic><sup><italic>trans</italic></sup>GKM was significantly higher in chromophobe compared to other subtypes (<italic>P</italic> < 0.01). Using <italic>K</italic><sup><italic>trans</italic></sup>GKM > 1.0 min<sup>−1</sup>, chromophobe were diagnosed with 100% sensitivity and 90.9% specificity. <italic>K</italic><sup><italic>trans</italic></sup>SSM2 was higher than <italic>K</italic><sup><italic>trans</italic></sup>GKM for all renal tumors except for all chromophobe and two clear cell subtype. Using <italic>K</italic><sup><italic>trans</italic></sup>GKM > 1.0 min<sup>−1</sup> and Δ <italic>K</italic><sup><italic>trans</italic></sup> < 0, chromophobe could be discriminated from other lesions with 100% accuracy.</p> </sec> <sec id="jmri24035-sec-0004" sec-type="section"> <title>Conclusion</title> <p> <italic>K</italic> <sup> <italic>trans</italic> </sup> obtained with GKM and SSM2 analysis can potentially discriminate chromophobe from other renal lesions with high accuracy. J. Magn. Reson. Imaging 2013;38:802–808. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>