Predictive value of apparent diffusion coefficient in evaluation of colorectal carcinoma hepatic metastases' response to radiofrequency ablation. Issue 5 (22nd March 2013)

• Record Type: Journal Article
• Authors: Szurowska, Edyta; Nowicki, Tomasz K.; Izycka‐Swieszewska, Ewa; Zadrozny, Dariusz; Markiet, Karolina; Studniarek, Michal
• Is Part Of: Journal of magnetic resonance imaging. Volume 38:Issue 5(2013)
• Page Start: 1027
• Page End: 1032
• Publication Date: 2013-03-22
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24089
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24089-sec-0001" sec-type="section"> <title>Purpose</title> <p>To establish the apparent diffusion coefficient (ADC) suitability to evaluate the radiofrequency ablation (RFA) outcome in patients with chemotherapy resistant or partially responding colorectal adenocarcinoma liver metastases.</p> </sec> <sec id="jmri24089-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>A total of 56 patients with 116 metastatic foci over 10 mm in diameter were examined with 1.5 Tesla MRI scanner 1 day before percutaneous RFA treatment. Lesions were evaluated in echo‐planar diffusion‐weighted images with b = 0, 15 and 500 s/mm<sup>2</sup>. On basis of computed tomography scan at 6 weeks, 3 and 6 months after RFA and serum CEA (carcinoembryonic antigen) level lesion were recognized as responding or nonresponding lesions. ADC values for b = 0–15 and 0–500 s/mm<sup>2</sup> of responding and nonresponding lesions were compared.</p> </sec> <sec id="jmri24089-sec-0003" sec-type="section"> <title>Results</title> <p>Noncomplete ablation concerned 28 lesions. Mean pretreatment ADC values for b = 0–15 and 0–500 s/mm<sup>2</sup> of responding metastases were significantly lower (2.14 and 1.48 × 10<sup>−3</sup> mm<sup>2</sup>/s) than those of nonresponding tumors (2.7 and 1.74 × 10<sup>−3</sup> mm<sup>2</sup>/s). Sensitivity, specificity, and accuracy of ADC values for b = 0–15 s/mm<sup>2</sup> were 79 (95%CI = 59–92), 85 (95%CI = 76–92), 84%; and for b = 0–500 s/mm<sup>2</sup>, the efficacy parameters were, respectively, 78 (95%CI = 56–92), 78 (95%CI = 67–86), and 78%. The <italic>P</italic> value was under 0.001 for both <italic>b</italic> parameters.</p> </sec> <sec id="jmri24089-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The pretreatment ADCs values of chemotherapy resistant or partially responding colorectal adenocarcinoma liver metastatic lesion can be predictive factor of tumors response to RFA therapy. J. Magn. Reson. Imaging 2013;38:1027–1032. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>