Multiparametric MRI for prostate cancer localization in correlation to whole‐mount histopathology. Issue 6 (21st November 2012)

• Record Type: Journal Article
• Authors: Isebaert, Sofie; Van den Bergh, Laura; Haustermans, Karin; Joniau, Steven; Lerut, Evelyne; De Wever, Liesbeth; De Keyzer, Frederik; Budiharto, Tom; Slagmolen, Pieter; Van Poppel, Hendrik; Oyen, Raymond
• Is Part Of: Journal of magnetic resonance imaging. Volume 37:Issue 6(2013)
• Page Start: 1392
• Page End: 1401
• Publication Date: 2012-11-21
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.23938
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Purpose:</title> <p>To prospectively evaluate multiparametric magnetic resonance imaging (MRI) for accurate localization of intraprostatic tumor nodules, with whole‐mount histopathology as the gold standard.</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Materials and Methods:</title> <p>Seventy‐five patients with biopsy‐proven, intermediate, and high‐risk prostate cancer underwent preoperative T2‐weighted (T2w), dynamic contrast‐enhanced (DCE) and diffusion‐weighted (DW) MRI at 1.5T. Localization of suspicious lesions was recorded for each of 24 standardized regions of interest on the different MR images and correlated with the pathologic findings. Generalized estimating equations (GEE) were used to estimate the sensitivity, specificity, accuracy, positive, and negative predictive value for every MRI modality, as well as to evaluate the influence of Gleason score and pT‐stage. Tumor volume measurements on histopathological specimens were correlated with those on the different MR modalities (Pearson correlation).</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Results:</title> <p>DW MRI had the highest sensitivity for tumor localization (31.1% vs. 27.4% vs. 44.5% for T2w, DCE, and DW MRI, respectively; <italic>P</italic> < 0.005), with more aggressive or more advanced tumors being more easily detected with this imaging modality. Significantly higher sensitivity values were obtained for the combination of T2w, DCE, and DW MRI (58.8%) as compared to each modality alone or any combination of two modalities (<italic>P</italic> < 0.0001). Tumor volume can most accurately be assessed by means of DW MRI (<italic>r</italic> = 0.75; <italic>P</italic> < 0.0001).</p> </sec> <sec id="abs1-4" sec-type="section"> <title>Conclusion:</title> <p>Combining T2w, DCE, and DW imaging significantly improves prostate cancer localization. J. Magn. Reson. Imaging 2013;37:1392–1401. © 2012 Wiley Periodicals, Inc.</p> </sec> </abstract>