Isometric handgrip exercise during cardiovascular magnetic resonance imaging: Set‐up and cardiovascular effects. Issue 6 (24th January 2013)

• Record Type: Journal Article
• Authors: von Knobelsdorff‐Brenkenhoff, Florian; Dieringer, Matthias A.; Fuchs, Katharina; Hezel, Fabian; Niendorf, Thoralf; Schulz‐Menger, Jeanette
• Is Part Of: Journal of magnetic resonance imaging. Volume 37:Issue 6(2013)
• Page Start: 1342
• Page End: 1350
• Publication Date: 2013-01-24
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.23924
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Purpose:</title> <p>To establish a suitable setup for combining isometric handgrip exercise with cardiovascular magnetic resonance (CMR) imaging and to assess cardiovascular effects.</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Materials and Methods:</title> <p>Fifty‐three healthy volunteers (31 males, mean age 45 ± 17 years) underwent handgrip exercise in a 3T scanner using a prototype handgrip system and a custom‐made feedback system that displayed the force. Handgrip was sustained at 30% of the maximal contraction for 6–8 minutes. Heart rate, blood pressure (BP), and double product were determined sequentially. Stroke volume was quantified in a subgroup (<italic>n</italic> = 21) at rest and stress using phase contrast acquisitions.</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Results:</title> <p>Heart rate increased significantly between rest and stress by 20 ± 13%, systolic / diastolic / mean BP by 15 ± 11% / 20 ± 18% / 17 ± 13%, double product by 37 ± 21%, and cardiac output by 27 ± 16% (each <italic>P</italic> < 0.001). Stroke volume did not significantly increase (3 ± 9%; <italic>P</italic> = 0.215). Higher age was associated with reduced increase of stroke volume (<italic>P</italic> = 0.022) and cardiac output (<italic>P</italic> < 0.001). Overweight subjects showed less increases in heart rate (<italic>P</italic> = 0.021) and cardiac output (<italic>P</italic> = 0.002).</p> </sec> <sec id="abs1-4" sec-type="section"> <title>Conclusion:</title> <p>The handgrip exercise during CMR with the presented set‐up leads to considerable hemodynamic changes in healthy volunteers. J. Magn. Reson. Imaging 2013;37:1342–1350. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>