Two‐dimensional J‐resolved proton MR spectroscopy and prior knowledge fitting (ProFit) in the frontal and parietal lobes of healthy volunteers: Assessment of metabolite discrimination and general reproducibility. Issue 3 (10th October 2012)

• Record Type: Journal Article
• Authors: Prescot, Andrew P.; Renshaw, Perry F.
• Is Part Of: Journal of magnetic resonance imaging. Volume 37:Issue 3(2013)
• Page Start: 642
• Page End: 651
• Publication Date: 2012-10-10
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.23848
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Purpose:</title> <p>To investigate human brain metabolite discriminability and general measurement reproducibility of two‐dimensional (2D) <italic>J</italic>‐resolved <sup>1</sup>H MRS and Prior Knowledge Fitting (ProFit).</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Materials and Methods:</title> <p>2D <italic>J</italic>‐resolved <sup>1</sup>H MRS spectra were acquired from the anterior cingulate cortex (ACC) and the parietal‐occipital cortex (POC) of 10 healthy subjects at a magnetic field strength of 2.9 Tesla. Amplitude correlation matrices were constructed for each subject and brain region to assess metabolite discriminability. ProFit‐estimated metabolite peak areas were normalized to a water reference signal, and intra‐ and inter‐subject reproducibility was evaluated.</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Results:</title> <p>Favorable between‐metabolite correlation coefficients (<20%) were observed for a range of metabolites. Lower correlation coefficients between a given pair of metabolite estimates were consistently observed for POC metabolites. The group mean correlation coefficient existing between glutamate and glutamine was calculated as −18% and −13% for ACC and POC, respectively. Most ACC and POC metabolites showed intra‐ and inter‐subject CV values of <15% and <20%, respectively.</p> </sec> <sec id="abs1-4" sec-type="section"> <title>Conclusion:</title> <p>The observed Glu and Gln signal discrimination makes these techniques suitable for investigating a variety of psychiatric disorders. Intra‐ and inter‐subject metabolite level reproducibility was comparable to the existing literature findings. These data serve as a valuable benchmark for assessing future modifications to 2D <sup>1</sup>H MRS data acquisition and ProFit analysis. J. Magn. Reson. Imaging 2013;37:642–651. © 2012 Wiley Periodicals, Inc.</p> </sec> </abstract>