Changes in apparent diffusion coefficient and T2 relaxation during radiotherapy for prostate cancer. Issue 4 (23rd October 2012)

• Record Type: Journal Article
• Authors: Foltz, Warren D.; Wu, Andy; Chung, Peter; Catton, Charles; Bayley, Andrew; Milosevic, Michael; Bristow, Robert; Warde, Padraig; Simeonov, Anna; Jaffray, David A.; Haider, Masoom A.; Ménard, Cynthia
• Is Part Of: Journal of magnetic resonance imaging. Volume 37:Issue 4(2013)
• Page Start: 909
• Page End: 916
• Publication Date: 2012-10-23
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.23885
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Purpose:</title> <p>To evaluate regional and temporal changes in apparent diffusion coefficient (ADC) and T<sub>2</sub> relaxation during radiation therapy (RT) in patients with low and intermediate risk localized prostate cancer.</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Materials and Methods:</title> <p>Seventeen patients enrolled on a prospective clinical trial where MRI was acquired every 2 weeks throughout eight weeks of image‐guided prostate IMRT (78 Gy/39 fractions). ADC and T<sub>2</sub> quantification used entire prostate, central gland, benign peripheral zone, and tumor‐dense regions‐of‐interest, and mean values were evaluated for common response trends.</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Results:</title> <p>Overall, the RT responses were greater than volunteer measurement repeatability, and week 6 appeared to be an optimum time‐point for early detection. RT effects on the entire prostate were best detected using ADC (5–7% by week 2, <italic>P</italic> < 0.0125), effects on peripheral zone were best detected using T<sub>2</sub> (19% reduction at week 6; <italic>P</italic> = 0.004) and effects on tumors were best detected using ADC (14% elevation at week 6; <italic>P</italic> = 0.004).</p> </sec> <sec id="abs1-4" sec-type="section"> <title>Conclusion:</title> <p>ADC and T<sub>2</sub> may be candidate biomarkers of early response to RT warranting further investigation against clinical outcomes. J. Magn. Reson. Imaging 2013;37:909–916. © 2012 Wiley Periodicals, Inc.</p> </sec> </abstract>