Comparison of MRS and DWI in the diagnosis of prostate cancer based on sextant analysis. Issue 1 (21st September 2012)

• Record Type: Journal Article
• Authors: Li, Bo; Cai, Wenchao; Lv, Dongjiao; Guo, Xuemei; Zhang, Jue; Wang, Xiaoying; Fang, Jing
• Is Part Of: Journal of magnetic resonance imaging. Volume 37:Issue 1(2013)
• Page Start: 194
• Page End: 200
• Publication Date: 2012-09-21
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.23809
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Purpose:</title> <p>To evaluate apparent diffusion coefficient (ADC) value, metabolic ratio ((Cho + Cr)/Cit) and the combination of the two in identifying prostate malignant regions.</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Materials and Methods:</title> <p>Fifty‐six consecutive patients with prostate biopsy results were retrospectively recruited in this study. Transrectal ultrasound‐guided (TRUS) systemic prostate biopsies were used as a standard of reference. Mean ADC value and mean metabolic ratio (MMR) were calculated within each benign sextant region or malignant region. The efficiency of these two indices in prostate cancer (PCa) diagnosis is estimated in Fisher linear discriminant analysis (FLDA). The area under the receiver operating characteristic (ROC) curve was used to evaluate the distinguishing capacity of mean ADC, MMR, and the combination of the two in differentiating between noncancerous and cancerous cases.</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Results:</title> <p>There were significant differences for mean ADC value and MMR between malignant and benign regions. Weights of mean ADC value obtained by FLDA were much higher than those of MMR. In differentiating malignant regions, both ADC alone and combined ADC and metabolic ratio performed significantly better than MMR alone. However, accuracy improvements were not significant by using combined ADC and MMR than ADC alone.</p> </sec> <sec id="abs1-4" sec-type="section"> <title>Conclusion:</title> <p>DWI is more efficient than MR spectroscopic (MRS) in the detection of PCa in this study. Combined ADC and MMR performed significantly better than MMR alone in distinguishing malignant from benign region in prostate peripheral zone. J. Magn. Reson. Imaging 2013;37:194–200. © 2012 Wiley Periodicals, Inc.</p> </sec> </abstract>