Novel technique for MR elastography of the prostate using a modified standard endorectal coil as actuator. Issue 6 (10th October 2012)

• Record Type: Journal Article
• Authors: Thörmer, Gregor; Reiss‐Zimmermann, Martin; Otto, Josephin; Hoffmann, Karl‐Titus; Moche, Michael; Garnov, Nikita; Kahn, Thomas; Busse, Harald
• Is Part Of: Journal of magnetic resonance imaging. Volume 37:Issue 6(2013)
• Page Start: 1480
• Page End: 1485
• Publication Date: 2012-10-10
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.23850
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Purpose:</title> <p>To present a novel method for MR elastography (MRE) of the prostate at 3 Tesla using a modified endorectal imaging coil.</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Materials and Methods:</title> <p>A commercial endorectal coil was modified to dynamically generate mechanical stress (contraction and dilation) in a prostate phantom with embedded phantom "lesions" (6 mm diameter) and in a porcine model. Resulting tissue displacements were measured with a motion‐sensitive EPI sequence at actuation frequencies of 50–200 Hz. Maps of shear modulus G were calculated from the measured phase‐difference shear‐wave patterns.</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Results:</title> <p>In the G maps of the phantom, "lesions" were easily discernible against the background. The average G values of regions of interest placed in the "lesion" (8.2 ± 1.9 kPa) were much higher than those in the background (3.6 ± 1.4 kPa) but systematically lower than values reported by the vendor (13.0 ± 1.0 and 6.7 ± 0.7 kPa, respectively). In the porcine model, shear waves could be generated and measured shear moduli were substantially different for muscle (7.1 ± 2.0 kPa), prostate (3.0 ± 1.4 kPa), and bulbourethral gland (5.6 ± 1.9 kPa).</p> </sec> <sec id="abs1-4" sec-type="section"> <title>Conclusion:</title> <p>An endorectal MRE concept is technically feasible. The presented technique will allow for simultaneous MRE and MRI acquisitions using a commercial base device with minor, MR‐conditional modifications. The diagnostic value needs to be determined in further trials. J. Magn. Reson. Imaging 2013;37:1480–1485. © 2012 Wiley Periodicals, Inc.</p> </sec> </abstract>