Evaluating quantitative approaches to dynamic susceptibility contrast MRI among carotid endarterectomy patients. Issue 4 (23rd October 2012)

• Record Type: Journal Article
• Authors: Crane, David E.; Donahue, Manus J.; Chappell, Michael A.; Sideso, Ediri; Handa, Ashok; Kennedy, James; Jezzard, Peter; MacIntosh, Bradley J.
• Is Part Of: Journal of magnetic resonance imaging. Volume 37:Issue 4(2013)
• Page Start: 936
• Page End: 943
• Publication Date: 2012-10-23
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.23882
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Purpose:</title> <p>To evaluate two dynamic susceptibility contrast (DSC) quantification methods in symptomatic carotid artery disease patients undergoing carotid endarterectomy (CEA) surgery by comparing methods directly and assessing the reliability of each method in the hemisphere contralateral to surgery.</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Materials and Methods:</title> <p>Absolute cerebral blood flow (CBF) and volume (CBV) was calculated in putamen and sensorimotor gray matter of 17 patients using two methods: 1) The <italic>Bookend</italic> method that scales relative DSC images to CBV values calculated from the ratio of pre‐ and postcontrast T1‐weighted images, and 2) the <italic>Tail‐scaling</italic> method that uses the ratio of area under the tails of the venous and arterial concentration time‐courses to scale the DSC images.</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Results:</title> <p>There was a positive correlation between the methods with significant correlation post‐CEA (<italic>P</italic> < 0.035). Intersession correlation was greater when using the Tail‐scaling method contralateral to surgery (<italic>P</italic> < 0.004).</p> </sec> <sec id="abs1-4" sec-type="section"> <title>Conclusion:</title> <p>We have demonstrated correlation between methods that is significant after surgery and have found that the Tail‐scaling method produces better test–retest reliability than our implementation of the Bookend method. Results from this study suggest that DSC has the potential to measure hemodynamic changes after endarterectomy and future work is required to establish clinical value. J. Magn. Reson. Imaging 2013;37:936–943. © 2012 Wiley Periodicals, Inc.</p> </sec> </abstract>